Hedgehog (Hh) signaling is a widely studied signaling pathway because of its critical roles during development and in cell homeostasis. Vertebrate canonical and non‐canonical Hh signaling are typically assumed to be distinct and occur in different cellular compartments. While research has primarily focused on the canonical form of Hh signaling and its dependency on primary cilia – microtubule‐based signaling hubs – an extensive list of crucial functions mediated by non‐canonical Hh signaling has emerged. Moreover, amounting evidence indicates that canonical and (...) non‐canonical modes of Hh signaling are interlinked, and that they can overlap spatially, and in many cases interact functionally. Here, we discuss some of the many cellular effects of non‐canonical signaling and discuss new evidence indicating inter‐relationships with canonical signaling. We discuss how Smoothened (Smo), a key component of the Hh pathway, might coordinate such diverse downstream effects. Collectively, pursuit of questions such as those proposed here will aid in elucidating the full extent of Smo function in development and advance its use as a target for cancer therapeutics. (shrink)

We characterize some large cardinal properties, such as $\mu$-measurability and $P^2(\kappa)$-measurability, in terms of ultrafilters, and then explore the Rudin-Keisler (RK) relations between these ultrafilters and supercompact measures on $P_\kappa(2^\kappa)$. This leads to the characterization of $2^\kappa$-supercompactness in terms of a measure on measure sequences, and also to the study of a certain natural subset, $\mathrm{Full}_\kappa$, of $P_\kappa(2^\kappa)$, whose elements code measures on cardinals less than $\kappa$. The hypothesis that $\mathrm{Full}_\kappa$ is stationary (a weaker assumption than $2^\kappa$-supercompactness) is equivalent to (...) a higher order Lowenheim-Skolem property, and settles a question about directed versus chain-type unions on $P_\kappa\lambda$. (shrink)

This paper begins with a summary of an argument for epiphenomenalism and a review of the author's previous work on the self-stultification objection to that view. The heart of the paper considers an objection to this previous work and provides a new response to it. Questions for this new response are considered and a view is developed in which knowledge of our own mentality is seen to differ from our knowledge of external things.

This commentary begins by explaining how Mangan's important work leads to a question about the relation between non-sensory experiences and perception. Reflection on affect then suggests an addition to Mangan's view that may be helpful on this and perhaps some other questions. Finally, it is argued that acceptance of non-sensory experiences is fully compatible with epiphenomenalism.

Frank Jackson has abandoned his famous knowledge argument, and has explained why in a brief "Postscript on Qualia" . This explanation consists of a direct argument, and an attempt to explain away the intuition that lies at the heart of the knowledge argument. The direct argument is clarified and found to be subtly question-begging. The attempt to explain away the key intuition is reviewed and found to be inadequate. False memory traces, which Jackson mentions at the beginning of the direct (...) argument, are discussed and found not to materially affect the force of the knowledge argument. (shrink)

Argues that Dennett's apparent inability to commit ontologically on the being of intentionality can be resolved by regarding intentionality as realized at the ontological level of a pattern of social behavior.

Some philosophers have regarded the connection between hues and certain arousal or affective qualities as so intimate as to make them inseparable, and this “necessary concomitance view” has been invoked to defend functionalism against arguments based on inverted spectra. Support for the necessary concomitance view has sometimes been thought to accrue from experiments in psychology. This paper examines three experiments, two of which apparently offer support for the view. It argues that careful consideration of these experiments undermines this appearance of (...) support. General lessons are drawn concerning the problem that individual differences present for functionalism, and the difficulty of supporting strong conclusions about concomitance by using the methods of experimental psychology. (shrink)

Gilbert Harman (1990) seeks to defend psychophysical functionalism by articulating a representationalist view of the qualities of experience. The negative side of the present paper argues that the resources of this representationalist view are insufficient to ground the evident distinction between perception and (mere) thought. This failure makes the view unable to support the uses to which Harman wishes to put it. Several rescuing moves by other representationalists are considered, but none is found successful. Part of the difficulty in Harman's (...) (...) work is that he does not adequately specify the view he rejects. The positive aim of the present paper is to provide a robust intrinsic quality account of experience that offers advantages in comparison with Harman's view, and that plainly does not fall to any of the arguments he advances. (shrink)

Wilfrid Sellars has proposed a materialist account of sensation which relies in part on the postulation of special kinds of individuals. This postulational strategy appears to be analogous to the one that introduces such entities as electrons. After setting out Sellars' account, I focus on his application of the postulational strategy. I argue that this application requires the discovery of new effects for familiar properties; that this kind of discovery is disanalogous to what postulation usually does; and that this kind (...) of discovery cannot really be arrived at by postulation. I conclude that Sellars has not provided a successful, materialist account of sensation. (shrink)

Peter Carruthers offers a model that embraces first order representations and higher order representations or higher order thoughts . His model stipulates certain features of FORs and HOTs. Carruthers agrees with qualia realists that the FORs of his model are not adequate for phenomenal consciousness, and invokes HOTs to supply the required addition. It is argued that Carruthers' HOTs fail to provide anything that will enable him to account for phenomenal consciousness, i.e., that his model fails to include phenomenal consciousness (...) and thus provides no help in understanding human consciousness, animal consciousness, or the "hard problem". In "Natural Theories of Consciousness" Peter Carruthers describes a model that he claims will show the "hard problem" to be not so hard after all. To evaluate this claim, we should begin with the model, which contains the following elements and stipulations. (shrink)

William S. Robinson has for many years written insightfully about the mind-body problem. In Understanding Phenomenal Consciousness he focuses on sensory experience and perception qualities such as colours, sounds and odours to present a dualistic view of the mind, called Qualitative Event Realism, that goes against the dominant materialist views. This theory is relevant to the development of a science of consciousness which is now being pursued not only by philosophers but by researchers in psychology and the brain sciences. (...) This provocative book will interest students and professionals who work in the philosophy of mind and will also have cross-disciplinary appeal in cognitive psychology and the brain sciences. (shrink)

This paper is a commentary on Joseph Corabi’s “The Misuse and Failure of the Evolutionary Argument”, this Journal, vol. VI, No. 39; pp. 199-227. It defends William James’s formulation of the evolutionary argument against charges such as mishandling of evidence. Although there are ways of attacking James’s argument, it remains formidable, and Corabi’s suggested revision is not an improvement on James’s statement of it.

The theory-theory claims that the explanation and prediction of behavior works via the application of a theory, while the simulation theory claims that explanation works by putting ourselves in others' places and noting what we would do. On either account, in order to develop a prediction or explanation of another person's behavior, one first needs to have a characterization of that person's current or recent actions. Simulation requires that I have some grasp of the other person's behavior to project myself (...) upon; whereas theorizing requires a subject matter to theorize about. The frame problem shows that multiple, true characterizations are possible for any behavior or situation. However, only one or a few of these characterizations are relevant to explaining or predicting behavior. Since different characterizations of a behavior lead to different predictions or explanations, much of the work of interpersonal interpretation is done in the process of finding this characterization - that is, prior to either theorizing or simulating. Moreover, finding this characterization involves extensive knowledge of the physical, cultural, and social worlds of the persons involved. (shrink)

Recent criticisms of epiphenomenalism include a meaning objection. This is a self-stultification objection according to which epiphenomenalism is incoherent, because phenomenal terms could not mean what epiphenomenalists say they mean if epiphenomenalism were true. This paper seeks to remove the sting of this objection by showing that one can construct a coherent epiphenomenalist theory of meaning from any coherent account that may be offered by a phenomenal realist physicalist. This argument bears adversely on an important argument offered by Balog , (...) and some arguments given in support of her view can be re-targeted as arguments against my conclusion. These arguments are reviewed and answered. (shrink)

Abstract: Receptivity is a foundational concept in the analysis of causation given in Gregg Rosenberg’s A Place for Consciousness and it enters, directly or indirectly, into the definitions of a host of other terms in the book. This commentary raises a problem (which I call “the triviality problem”) about how we are to understand receptivity. Search for a solution proceeds by examination of several contexts in which the concept of receptivity is used. Although a satisfactory solution remains elusive, it is (...) hoped that making the problem clear will lead to its eventual resolution. (shrink)

Argues that choice, as a form of interpretation, is completely intertwined with the development of both sexual orientation and sexual identity. Sexual orientation is not simply a given, or determined aspect of personality.

. An attempt is made to identify a concept of ‘downward causation’ that will fit the claims of some recent writers and apply to interesting cases in biology and cognitive theory, but not to trivial cases. After noting some difficulties in achieving this task, it is proposed that in interesting cases commonly used to illustrate ‘downward causation’, (a) regularities hold between multiply realizable properties and (b) the explanation of the parallel regularity at the level of the realizing properties is non-trivial. (...) It is argued that the relation between a realizable property and the property that realizes its effect in a particular case is not usefully regarded as a species of causation and that use of the concept of downward causation deflects our attention from our central explanatory tasks. (shrink)

We investigated the properties of the sustained attention to response task . In the SART, participants respond to frequent neutral signals and are required to withhold response to rare critical signals. We examined whether SART performance shows characteristics of speed–accuracy tradeoffs and in addition, we examined whether SART performance is influenced by prior exposure to emotional picture stimuli. Thirty-six participants in this study performed SARTs after being exposed to neutral and negative picture stimuli. Performance in the SART changed rapidly over (...) time and there was a high correlation between participants errors of commission rate and their reaction time to the neutral targets . Regardless of exposure self-reported thoughts significantly correlated with both errors of commission and reaction times. Overall, the results support the view that the SART is a better measure of impulsive responding than sustained attention. (shrink)

In a careful exposition of French Marxism, William Lewis places Althusser and his thought alongside the pre- and post-war French communist intellectual climate: the result is an excellent and unique work. Part theoretical treatise on some of Althusser's more complicated and less explored ideas, part intellectual history, Louis Althusser and the Traditions of French Marxism is, in total, an important text for philosophy, French and francophone studies, political thought, cultural studies, marxist thought, and several other disciplines interested in the (...) intellectual life and times of the twientieth century. (shrink)

Critics of SRI have said little about the integrity of corporate representations resulting in screening inclusion or exclusion. This is surprising given social and environmental accounting research that finds corporate posturing and deception in the absence of external verification, and a parallel body of literature describing corporate "greenwashing" and other forms of corporate disinformation. In this paper I argue that the problems and challenges of ensuring fair and accurate corporate social reporting mirror those accompanying corporate compliance with law. Similarities and (...) points of convergence between social reporting and corporate compliance are discussed, along with proposals for reform. (shrink)

Exploration of Alfred North Whitehead's influence on Maurice Merleau-Ponty's ontology of nature.

This paper evaluates the rhetoric of the U.S. bishops' pastoral letter on the U.S. economy from two perspectives. Is the letter convincing? Does it conform to the conversational norms of civilization? The paper argues that the bishops' letter fails by both standards because it ignores serious research on the U.S. economy, it misstates important facts about the economy, and it sneers at professional economists. The paper concludes that the bishops' letter will not be convincing to well informed readers.

As part of a defense of a physicalist view of experiences, David Papineau has offered an explanation for the intuition that properties found in experiences are distinct from neural properties. After providing some necessary background, I argue that Papineau’s explanation is not the best explanation of the distinctness intuition. An alternative explanation that is compatible with dualism is offered. Unlike Papineau’s explanation, this alternative does not require us to suppose that the distinctness intuition rests on fallacious reasoning. Relations of the (...) alternative explanation to representationalism and to cases of genuine property identity are discussed. (shrink)

This article defends epiphenomenalism against criticisms raised in Dwayne Moore’s “On Robinson’s Response to the Self-Stultifying Objection”.

Silent thinking is often accompanied by subvocal sayings to ourselves, imagery, emotional feelings, and non-sensory experiences such as familiarity, rightness, and confidence that we can go on in certain ways. Phenomenological materials of these kinds, along with our dispositions to give explanations or draw inferences, provide resources that are sufficient to account for our knowledge of what we think, desire, and so on. We do not need to suppose that there is a distinctive, non-imagistic 'what it is like' to think (...) that p, and a different non-imagistic 'what it is like' to think that q. Nor need we suppose that there is a proprietary 'what it is like' to have one propositional attitude type rather than another. (shrink)

_Exploration of Alfred North Whitehead's influence on Maurice Merleau-Ponty's ontology of nature._.

The development and consultation experience of an ethics committee in an urban community hospital has been presented, and various approaches to case consultation have been considered. Our committee has concentrated on the clinical evaluation model. As expected, most consultations have centered on issues of withdrawing or limiting medical care. Most patients evaluated have been unable to clearly express their wishes concerning further treatments, highlighting the need for promoting advance directives. When resorting to substituted judgment, our committee has supported continued care (...) in a majority of cases. Limitation of the consultation process to the attending physician has, in our experience, actually served to increase the credibility of the committee and has promoted acceptance of its recommendations. The committee's most useful function seems to be in assisting physicians and their patients in defining realistic goals and limitations of treatment. Within this context, the coming decade may find ethics committees concerned less with promoting the autonomous wishes of individual patients than with defining the limits of that autonomy against the competing demands of the larger society. Such a shift be approached with caution. (shrink)

In this article we challenge the notion that diversity serves as a good proxy for educational justice. First, we maintain that the story about how diversity might be accomplished and what it might do for students and society is internally inconsistent. Second, we argue that a disproportionate share of the benefits that might result from greater diversity often accrues to those already advantaged. Finally, we propose that many of the most promising and pragmatic remedies for educational injustice are often rejected (...) by liberal proponents of “diversity first” in favor of remedies that in most cases are practically impossible, and often problematic on their own terms. We argue that schools that are by geography and demography not ethnically or socioeconomically diverse still can successfully confront the obstacles that their students face in creating a life they have reason to value. (shrink)

Shoemaker argues that a satisfactory resolution of Moore's paradox requires a _self-intimation thesis that posits a "constitutive relation between belief and believing that one believes." He claims that such a thesis is needed to explain the crucial fact that the assent conditions for '_P' entail those for '_I believe that P'. This paper argues for an alternative resolution of Moore's paradox that provides for an adequate explanation of the crucial fact without relying on the kind of necessary connection between first (...) and second-order beliefs that is posited by Shoemaker's self-intimation thesis. (shrink)

Contemporaries often reject epiphenomenalism out of hand, while Russellian Monism is regarded as worthy of further development. It is argued here that this difference of attitudes is indefensible, because the easy rejection of EPI is due to its violating a certain Causal Intuition, and RM implicitly violates that same intuition. An enriched version of RM mitigates the violation, but the same mitigation results if we make a parallel enrichment of EPI. If RM and EPI are approached on a level playing (...) field, it is not obvious which will prove to be the better view. (shrink)

Daniel Dennett (1991) has advanced a mild realism in which beliefs are described as patterns “discernible in agents' (observable) behavior” (p. 30). I clarify the conflict between this otherwise attractive theory and the strong realist view that beliefs are internal states that cause actions. Support for strong realism is sometimes derived from the assumption that the everyday psychology of the folk is committed to it. My main thesis here is that we have sufficient reason neither for strong realism nor for (...) the supporting assumption about the commitments of folk psychology. Several generally implicit arguments in support of the latter assumption are considered. Explicit arguments for it by Ramsey et al. (1990) and Wellman (1990) are examined and judged unsuccessful. An explicit argument for strong realism by Cummins (in conversation) is also found inadequate. Consideration of this latter argument helps to explain why we cannot be satisfied with Dennett's own very brief discussion of causation by beliefs. (shrink)

Silent thinking is often accompanied by subvocal sayings to ourselves, imagery, emotional feelings, and non-sensory experiences such as familiarity, rightness, and confidence that we can go on in certain ways. Phenomenological materials of these kinds, along with our dispositions to give explanations or draw inferences, provide resources that are sufficient to account for our knowledge of what we think, desire, and so on. We do not need to suppose that there is a distinctive, non-imagistic ‘what it is like’ to think (...) that p, and a different non-imagistic ‘what it is like’ to think that q. Nor need we suppose that there is a proprietary ‘what it is like’ to have one propositional attitude type rather than another. (shrink)

Robert Nozick (1993) has offered an evolutionary account of self-evident beliefs that comes into conflict with a "mild realist" (Dennett, 1991a) view of beliefs. This chapter summarizes both views, and explains the conflict. Emergence is examined. Mild realism is found to embrace "emergence" in an acceptable sense, and to eschew it in its problematic sense. Nozick's cases of self-evident beliefs are examined and difficulties in his account are explained. An alternative approach is developed that avoids the difficulties in Nozick's account (...) and is compatible with mild realism. Implications of mild realism for concepts are drawn. (shrink)

This essay takes a synthetic and critical approach to the scattered pieces of art criticism and aesthetic theory authored by Louis Althusser. Connecting these texts to his larger philosophical and political project, we argue that these reflections make an independent contribution to its worth and that they offer different perspectives on lingering theoretical problems. We piece together the insights that form the core of the Althusserian approach to aesthetics and show how these are formulated (in connection with the work of (...) Pierre Macherey as well as the dominant controversies of the time) and trace how their formulations take shape in relation to the work of different authors and artists. In addition to helping us better understand his overall project, Althusser’s aesthetic theory is, we argue, a powerful and original contribution to Marxist aesthetics. Specifically, it points us to the idea that we need to take aesthetic production seriously as a practice with its own specificity - one that has its own logics of determination, rituals of production, circulation, and consumption, one that commands effects that need to be theorized on their own terms. (shrink)

In this paper we consider the potential role of metarepresentation—the representation of another representation, or as commonly considered within cognitive science, the mental representation of another individual's knowledge and beliefs—in mediating definite reference and common ground in conversation. Using dialogues from a referential communication study in which speakers conversed in succession with two different addressees, we highlight ways in which interlocutors work together to successfully refer to objects, and achieve shared conceptualizations. We briefly review accounts of how such shared conceptualizations (...) could be represented in memory, from simple associations between label and referent, to “triple co-presence” representations that track interlocutors in an episode of referring, to more elaborate metarepresentations that invoke theory of mind, mutual knowledge, or a model of a conversational partner. We consider how some forms of metarepresentation, once created and activated, could account for definite reference in conversation by appealing to ordinary processes in memory. We conclude that any representations that capture information about others' perspectives are likely to be relatively simple and subject to the same kinds of constraints on attention and memory that influence other kinds of cognitive representations. (shrink)